Recombinant DNA technology- a game changer in cancer biology

Focused View

Sumitra Shankar

1:33:50

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1 - Introduction

1 - Introduction.mp4

04:05

2 - Chemical theory

2 - Somatic mutation hypothesis.mp4

03:53

3 - Ames test.mp4

03:47

3 - Chromosomal theory

4 - Experiments to identify chromosomal aberrations.mp4

04:31

5 - Experiments identifying DNA mRNA and protein.mp4

06:38

4 - Viral theory

6 - Peyton Rous RSV and Viral theory.mp4

04:33

6 - SECTION-2-3-4-for-pdf-file.pdf

5 - Tumor viruses and their role in Cancer research

7 - RSV infection fate of cells and influence on tumor formation.mp4

04:46

8 - Proviral theory.mp4

06:14

9 - Reverse transcriptase and Integrase.mp4

03:18

10 - Quiz on RSV experiments.txt

10 - RSV experiments Quiz.html

6 - Hunt for protooncogenes

11 - Varmus and Bishop experiment.mp4

06:14

12 - Src Kinase and search for other oncogenes.mp4

04:02

13 - leukemogenesis theory.mp4

02:47

14 - Hunt for protooncogenes.txt

14 - Hunt for protooncogenes quiz.html

7 - Nonviral mehanism of tumorigenesis

15 - DNA transfection experiment.mp4

05:15

16 - Are viral and nonviral mechanisms different.mp4

02:33

17 - Different mechanism of mutations for oncogenes.mp4

01:39

18 - Nonviral mehanism of tumorigenesis.txt

18 - Nonviral mehanism of tumorigenesis Quiz.html

8 - Discovery of tumor suppressor genes

19 - Cell fusion experiment.mp4

02:19

20 - Knudson hypothesis.mp4

02:09

21 - Loss of heterozygosity.mp4

05:35

22 - Identification of pRB gene.mp4

08:13

23 - Identification of p53 gene.mp4

08:49

24 - Tumor suppressors.html

24 - Tumor suppressors Quiz time.txt

9 - Wrap Up

25 - Conclusion.mp4

02:30

26 - BONUS.html

Description

Anecdotes in cancer biology revealing experimental strategies that revolutionized the field of oncology

What You'll Learn?

Different theories about cancer namely- chemical, chromosomal and viral, formed pieces of a puzzle that led to the birth of Oncogenes and Tumor suppressors
Explore how tumor viruses revealed a bigger picture of cancer and also how identification of some of the viruses contributed to rDNA technology
How cloning strategies accelerated the understanding of molecular dimension of carcinogenesis
Learn about the non-viral mechanism of tumorigenesis and the different mechanism of mutations occurring in cancer cells

Who is this for?

High school students, college freshers and research students who are inquisitive enough to dig deeper into the powerful observations, brilliant experimental strategies and different theories about cancer that shaped the field of cancer biology we know today

This course is not for absolute beginners who are looking for a typical in-depth college curriculum and not for experts in the field who are looking for advanced knowledge.

This course would aid research students in tapping into the collective historical wisdom of the pioneers and use them as a guide in further advancing this field.

What You Need to Know?

Students must be familiar with recombinant DNA tools and techniques and concepts of cloning

Students must know basic concepts and terms in molecular biology such as DNA, mRNA, chromosomes, mitosis, meiosis etc.

More details

Description
This course on cancer biologyÂ focuses on historical theories andÂ cloning strategies put forth to comprehend carcinogenesis.
The objective is to travel back in time to the period when all the pieces of puzzle such as chemical carcinogens, retroviruses and chromosomal mutations came together to reveal the grand scheme of cancer and propose the underlying criteria for cancer development.
The highlights of this lecture series are the experimental methods developed during 1960s to 1990s which built the foundation for the currentÂ model of cancer which stems from two concepts namely- oncogenes and tumor suppressor genes.
You'll learn about Ames test, pro-viral theory, the discovery of reverse transcriptase, Leukemogenesis theory, different mechanisms of tumor cell mutations occurring in the cells, knudson hypothesis and much more.
You'll learn-
Chemical theory section explains the formation of cancer. Somatic mutation hypothesis and Ames test are concepts covered under chemical theory
Chromosomal theory section covers the experiments done to show that chromosomal aberrations cause cancer.
Viral theory section deals with Rous sarcoma virus, pro-viral theory, the discovery of reverse transcriptase, Leukemogenesis theory.
The experiments that indicated the presence of proto-oncogenes and different mechanisms of mutations occurring in cancer cells.
If oncogenes are like accelerators in the car, then tumor suppressors are like brakes. Learn about the cell fusion experiment, Knudson hypothesis and loss of heterozygosity.
How p53 (the guardian of the genome) and pRb tumor suppressors were discovered.
As is with any course, this course is also backed by Udemy's 30 day money back guarantee.
If you're not happy for any reason you will get a full refund.
So take this course today, and get deeper insights in cancer biology.
Who this course is for:
High school students, college freshers and research students who are inquisitive enough to dig deeper into the powerful observations, brilliant experimental strategies and different theories about cancer that shaped the field of cancer biology we know today
This course is not for absolute beginners who are looking for a typical in-depth college curriculum and not for experts in the field who are looking for advanced knowledge.
This course would aid research students in tapping into the collective historical wisdom of the pioneers and use them as a guide in further advancing this field.

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Biology

Sumitra Shankar

Instructor's Courses

Science is my fascination. This has fueled my journey right from my Bachelors program, through the Masters and finally my PhD in Biotechnology (Kerala University, India). Over the years, I have donned myriad garbs of a student (I qualified CSIR -Council for Scientific and Industrial Research exam in 2008), researcher, lab-mate and senior, and have benefited from timely guidance, elaborate reading, and unexpected insights. The key to success has always been in grasping the bigger picture. I am passionate about passing on this experience through teaching. I believe that through this, my own learning and understanding skills can also be enhanced.

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